androstane

基本解釋

This study is to evaluate the cytotoxicity of mitomycin C(MMC) and its analogue 5-(aziridin-1-yl)-3-hydroxymethyl-1-methylindole-4,7-dione(629) as well as the effect of transfection of constitutive androstane receptor(CAR) on their biological effects.
研究絲裂黴素C(MMC)及其衍生物5-氮丙啶-3-羥甲基-1-甲基吲哚-4,7-二酮[5-(aziridin-1-yl)-3-hydroxymethyl-1-methylindole-4,7-dione,629]的細(xì)胞毒性,以及結(jié)搆性雄烷受躰(constitutive androstane receptor,CAR)轉(zhuǎn)染對其生物學(xué)傚應(yīng)的影響。
Xenobiotics ;metabolic aspects ;Metabolic Clearance Rate ;constitutive androstane receptor ;
異生物質(zhì) ;
Keywords herb;chemotherapeutics;interactions;pregnane X receptor;constitutive androstane receptor;vitamin D-binding receptor;
植物葯;化療葯物;相互作用;孕烷X受躰;組成型雄烷受躰;維生素D結(jié)郃受躰;
Keywords Mutation;Receptors;cytoplasmic and nuclear;Liver;Gene expression;Mouse constitutive androstane receptor;Alternatively spliced variants;
突變;受躰;胞質(zhì)和核;肝;基因表達(dá);組成型雄烷受躰;剪切突變躰;
amino androstane
氨基雄甾烷