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CONCLUSION The CCD-RSM can be applied to optimize the formulation of butoconazole nitrate sustained-release cream and the established model is of satisfactory predictive value. 結(jié)論星點(diǎn)設(shè)計(jì)-傚應(yīng)麪法可用於硝酸佈康唑緩釋乳膏的処方優(yōu)化，所建模型具有良好的預(yù)測(cè)能力。